Gastrointestinal surgery
Conditions
Interventions
Lidocaine group:Before induction of anesthesia, lidocaine was injected 1.5mg / kg and the operation was started 30 minutes later. The anesthesia was maintained at a rate of 1.5mg / kg / h (if the pati
Saline group:Isovolume saline was administered in the remaining isolidocaine group (including intravenous start time, start of continuous pump infusion, and stop time).
Sponsors
And Sichuan Provincial Academy of Medical Sciences. Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients scheduled for elective gastrointestinal surgery; 2) ASA I-II level; 3) Age 18-65 years; 4) Surgery duration of 2-4 hours; 5) Willing to receive lidocaine intravenously, informed and willing to participate in this study, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Allergy or contraindications to lidocaine; 2) conduction block arrhythmia, sinus bradycardia, preexcitation syndrome, AS syndrome, atrial fibrillation, etc.; 3) Severe hepatic and renal dysfunction; 4) Serious mental illness, such as schizophrenia, depression, dementia, etc.; 5) Neuromuscular diseases; 6) Patients with difficult airway; 7) Pregnant women; weight 100kg; 8) History of chronic analgesics, long-term history of opioid drugs, alcohol or medication Abuse of things; 9) Taking other trial drugs three months before the study, participated in or are participating in other clinical trials; 10) Unable to cooperate with the study for any reason or the investigator considers unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Protein levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain VAS score;Postoperative inflammatory markers after 48 hours; | — |
Countries
China
Contacts
Public ContactXi Yang
Anesthesiology Department of Sichuan Provincial People's Hospital
Outcome results
None listed