major spine surgery
Conditions
Interventions
the Remimazolam Group:Remimazolam-flumazenil
Sponsors
The Second Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old, gender is not limited, elective spine surgery (expected operation duration= 3 hours). 2. ASA classification I-III, 18Kg/?<=BMI<=30kg/?. 3. Be able to understand the procedures and methods of this trial, be willing to strictly abide by the clinical research protocol to complete this trial, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Difficult airway, lung infection and acute stage of asthma. 2. Patients with recent myocarditis, endocarditis, history of heart failure or recent thrombosis (= 160mmHg and/or diastolic blood pressure >=90mmHg), diabetes mellitus (random blood glucose>=11.1 mmol/L). 4. Patients who are allergic to benzodiazepines, opioids, propofol or muscle relaxants, history of epilepsy, long-term alcohol dependence, and long-term drug abuse. 5. Patients with previous mental illness or taking psychotropic drugs, history of cognitive dysfunction or impaired consciousness. 6. Abnormal liver function, AST and/or ALT >= 2.5 × upper limit of normal, TBIL >= 1.5 × upper limit of normal. 7. Abnormal renal function, urea or urea nitrogen >= 1.5× upper limit of normal, and serum creatinine higher than the upper limit of normal. 8. Pregnant or lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of delayed emergence; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time to obey verbal command;the time to BIS over 80 ;the time to extubation;the length of the PACU stay (PACU LOS);adverse events throughout recovery.;Richmond Agitation-Sedation Scale (RASS) scores ;Modified Aldrete scores; | — |
Countries
China
Contacts
Public ContactRuping Dai
The Second Xiangya Hospital, Central South University
Outcome results
None listed