respiratory tract infections of extensively-drug resistant and pan-drug resistant pathogenic bacteria
Conditions
Interventions
bacteriophage therapy group:bacteriophage therapy in respiratory tract infections of extensively-drug resistant and pandrug-resistant pathogenic bacterias
Sponsors
College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. corresponding to diagnosis standards of hospital-acquired pneumonia, ventilator-associated pneumonia, or acute exacerbation of bronchiectasis 2.extensively-drug resistant or pandrug-resistant pathogenic bacterias were found in phlegm or BALF 3.the combination of two or more different kinds of antibiotics is ineffective, or can not tolerate the side effects of antibiotics 4. Informed consent is signed
Exclusion criteria
Exclusion criteria: 1.Age <14 years old; 2. Pregnant women; 3. inability to express the true will and the guardian does not agree ;4. Uncontrolled bronchial asthma; 5. Severe airway spasm and intolerance occurred during atomized inhalation in the past; 6. Antibiotic atomization therapy is required, and all antibiotics are antagonistic to bacteriophages
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine examination;CRP;IL-6;PCT;blood biochemistry; | — |
Countries
China
Contacts
Public ContactLixin Xie
College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital
Outcome results
None listed