coronary heart disease
Conditions
Interventions
Oxycodone group (group O) :Postoperatively, a disposable intravenous self-controlled analgesic pump was connected, and 0.8 mg/kg oxycodone hydrochloride (up to 100 mg) and ondansetron 4 mg were given.
Sufentanil group (group S).:Postoperatively, a disposable intravenous self-controlled analgesic pump was connected, and 1.5 ug/kg oxycodone hydrochloride (up to 150 ug) and ondansetron 4 mg were given
Sponsors
Yidu Central Hospital Affiliated to Shandong Second Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: Elective OPCABG was included; Patients aged 45-80 years; Patients requiring patient-controlled intravenous analgesia (PCIA) after surgery; Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Hypersensitivity to medications used during the study; History of chronic pain, alcohol, or recreational drug abuse at the time of admission; preoperative delirium or communication disorders; Concomitant valvular heart disease or ventricular aneurysm; Severe hepatic dysfunction (Child - Pugh Grade C), severe renal dysfunction (preoperative dialysis); It is expected that endotracheal intubation will continue to be used to assist breathing 24 hours after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe pain within 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score within 72 hours after surgery;Opioid consumption within 72 hours after surgery;Incidence of delirium within 72 hours after surgery;Extubation time;ICU stay time;Changes in stress factors ;Postoperative complications within 30 days ; | — |
Countries
China
Contacts
Public ContactHuayong Chen
Yidu Central Hospital Affiliated to Shandong Second Medical University
Outcome results
None listed