Lung adenocarcinoma
Conditions
Interventions
Surgical resection group:Lobectomy+ Sublobar resection
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age: >= 18 years old; sex-neutral, resectable NSCLC; 2. Solid nodules in the incomplete pulmonary fissure area, and the preoperative puncture confirmed NSCLC; 3. No history of ipsilateral thoracotomy, and no previous chemotherapy or radiotherapy for any malignant disease; 4. Normal function of major organs; (1) Routine blood examination: a.HB>=90g/L; b.ANC>=1.5x10^9/L; c.PLT>=80x10^9/L; (2) Biochemical examination: a. ALB > = 30 g/L: b. ALT and AST = 60 ml/min: 5. Doppler ultrasound assessment: left ventricular ejection fraction (LVEF) >= low limit of normal (50%); 6. Physical fitness score (ECOG) of 0, 1, or 2; 7. Subjects voluntarily joined the study, signed the informed consent form, had good compliance, and cooperated with follow-up
Exclusion criteria
Exclusion criteria: 1.active bacterial or fungous infection; 2.women during pregnancyor breast-feeding; 3.simultaneous or metachronous double cancers within the past 5 years; 4.Patients with a history of psychotropic drug abuse and inability to abstain or with mental disorders; 5.Uncontrolled diabetes or high blood pressure; 6.interstitial pneumonitis,pulmonary fibrosis,or severe pulmonary emphysema; 7.history of severe heart disease, heart failure, myocardial infarction within the past 6 months or attack of angina pectoris within the past 6 months. 8. According to the judgment of the investigator, patients with concomitant diseases (such as acute myocardial infarction, cerebral infarction, pulmonary embolism, etc.) that seriously endanger the safety of patients or affect the completion of the study 9.Patients considered unsuitable for this study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival(OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease Free Survival;post-operative respiratory function; | — |
Countries
China
Contacts
Public ContactXiangnan Li
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed