sepsis acute lung injury
Conditions
Interventions
Sivilastat sodium group:None
Without Sivilastat sodium group:
Sponsors
the 908th Hospital of Chinese Logistical Support Force
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Meet sepsis 3.0 criteria (infection or suspected infection + sequential organ failure score (SOFA) = 2); Oxygenation index= 300mmHg; Voluntary participation in this trial and informed consent.
Exclusion criteria
Exclusion criteria: Women who are pregnant, nursing, or may be pregnant; Patients who are allergic to the study drug; less than 7 days of medication and less than 7 days of hospital stay; Patients with a history of the following diseases: patients with severe heart, lung, renal, and hepatic insufficiency or immune disorders; Patients who have been treated with hormones, immunosuppressants and other drugs or have had organ transplantation within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2;Duration of mechanical ventilation;ICU duration and hospital stay ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Free DNA;Neutrophil elastase;prothrombin time;activated partial thromboplastin time;thrombin time;fibrinogen;fibrin degradation products;D-Dimer;antithrombin ;neutrophil-to-lymphocyte ratio;INF-?;Transforming growth factor beta; | — |
Countries
China
Contacts
Public ContactSong Jingchun
Department of Critical Care Medicine, the 908th Hospital of Chinese Logistical Support Force
Outcome results
None listed