Cardiac surgery
Conditions
Interventions
Observation group:The observation group received intravenous infusion of 2.0 µg/kg/h sufentanil and 2 mg/kg/hesketamine.
Control group : The control group received intravenous infusion of 2.5 µg/kg/h sufentanil
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients who need cardiac surgery after comprehensive clinical examination. 2.American Society of Anesthesiologists (ASA) Medical Conditions I to II. 3.Body mass index (BMI) less than 30 kg·m?². 4.The STOP-BANG score is less than 3 points. 5.Complete clinical data.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breastfeeding; 2. Severe, existing substantial liver disease with clinically significant portal hypertension, Child-Pugh C cirrhosis or acute liver failure; 3. Patients with acute and chronic renal insufficiency requiring dialysis; 4. Bronchial asthma or COPD, myasthenia gravis patients; 5. Patients with a history of alcohol or drug abuse; 6. Long-term oral sedative, anti-insomnia, anti-anxiety drugs 7. Patients who take long-term immunosuppressants or hormones; 8. There are symptoms of delirium and alcohol withdrawal; 9. Patients with severe pulmonary hypertension combined with Eisenmenger syndrome; 10. Circulatory or hemodynamic instability requires supporters of mechanical devices such as ECMO and IABP; 11. Severe craniocerebral injury, brain tumor, increased intracranial pressure, cerebrovascular accident, coma, status epilepticus; 12. Any condition that prevents the correct assessment of cognitive function, such as language and sensory disturbances or psychiatric disturbances (language difficulties or psychoorganic dysfunction); 13. Allergy to the research drug or other contraindications; 14. The patient himself or his legally authorized representative is unwilling to sign the informed consent; 15. There are factors that increase the risk associated with participating in the study (such as the presence of severe hypotension), which is not suitable for inclusion in the study according to the investigator's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score;Depression score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Mean arterial pressure;Oxygen saturation; | — |
Countries
China
Contacts
Public ContactWeicai Xu
Zhejiang Provincial People's Hospital, Gongshu District, Hangzhou City, Zhejiang Province
Outcome results
None listed