radiodermatitis
Conditions
Interventions
Selenium supplement group:The study group also took 300µg nano-selenium capsules orally once a day, starting from 14 days before radiotherapy until 90 days after oral administration.
Control group:None
Sponsors
Jieyang People’s Hospital (Jieyang Affiliated Hospital, Sun Yatsen University)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Pathological examination confirmed unilateral invasive breast carcinoma, including ductal carcinoma, lobular carcinoma, tubule carcinoma, mucinous adenocarcinoma, papillary carcinoma, mixed type and metaplastic carcinoma; 2.The surgical method was breast cancer mastectomy; 3. Postoperative adjuvant radiotherapy needs to irradiate lymph nodes in the +/- region of the chest wall; 4.ECOG physical status score is 0-2 points; 5. the age has reached 18 years old, and there is no "exclusion criteria"; 6.Voluntarily participate in the experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Have a history of allergic reaction to selenium or selenium-containing drugs; 2. Patients who take selenium-rich health care products for a long time; 3.There are oral drug disorders; 4.Known history of primary immunodeficiency; 5.Pregnant or lactating women; 6.At the time of diagnosis, there are serious medical complications, dysfunction of important organs (heart, lung, liver, kidney) or neuropsychiatric diseases; 7.Previous history of cervical and thoracic radiotherapy; 8.Other contraindications to radiotherapy or cases that could not be included in the study as assessed by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of radiation dermatitis above grade 2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood selenium and selenase levels;Radiation lung injury, hematological toxicity;Regulation of anti-tumor immune response in vivo; | — |
Countries
China
Contacts
Public ContactFanjun Meng
Jieyang People’s Hospital (Jieyang Affiliated Hospital, Sun Yatsen University)
Outcome results
None listed