Primary aldosteronism
Conditions
Interventions
Primary aldosteronism:Microwave ablation
Primary aldosteronism:Laparoscopic adrenal adenomatectomy
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old and = 75 years old; 2. PA patients who can be diagnosed with primary aldosteronism (PA) according to the consensus of the 2020 version of China and meet the surgical indications for unilateral adrenal adenoma. (1) Age 3, and dominant side index (LI) > 4; b. Non-adrenocorticotropic hormone-stimulated AVS: SI > 2, and LI > 3, and contralateral inhibitory index (CSI) < 0.5/1. 3. Clinically judged to be suitable for microwave ablation therapy and adrenal surgery (as determined in MDT diagnosis and treatment), able and willing to give informed consent, and agree to undergo follow-up and undergo corresponding examinations during follow-up.
Exclusion criteria
Exclusion criteria: 1. Absolute contraindication to alpha or beta-adrenergic receptor antagonists, or inability to discontinue beta-adrenergic receptor antagonist therapy for 2 weeks; 2.Contraindications for adrenal adenoma microwave ablation or laparoscopic surgery, including: contrast agent allergy, severe heart failure (NYHA class III/IV), cerebrovascular structural abnormalities with bleeding risk, blood pressure >180/110 mmHg, and coagulopathy; 3. Pregnancy or unwillingness to use reliable contraception during the study (female participants only); 4.Life-limiting comorbidities (as determined by the Principal Investigator); 5. Co-secretion of cortisol (all participants will undergo a low-dose dexamethasone suppression test); 6. HIV infection and/or active tuberculosis infection; 7. Unwillingness to undergo microwave ablation therapy or adrenal surgery, or unwillingness to comply with the study visit schedule.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aldosterone;Renin;ARR;Blood pressure;Types and doses of antihypertensive drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrolyte;Renal function; | — |
Countries
China
Contacts
Public ContactMing Liu
Tianjin Medical University General Hospital
Outcome results
None listed