Chronic kidney disease
Conditions
Interventions
Index test:3.0T multi-parameter functional magnetic resonance imaging technology, including DWI, DTI, IVIM, BOLD, T1 mapping, ASL, etc.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Population with high risk factors of CKD, suspected CKD and planned to undergo renal biopsy, such as proteinuria, hematuria, increased serum creatinine level, decreased eGFR, abnormal renal color Doppler ultrasound; 2. The control group was healthy volunteers without any kidney disease, with or without other system diseases. If there were other system diseases, it would not affect the structure and function of the kidney; This includes the following: (1) No history of hypertension, diabetes and other basic diseases; (2) No history of hydronephrosis, nephrolithiasis or nephritis; (3) normal urine routine and renal function in recent half a year; (4) no recent use of nephrotoxic drugs; (5) can cooperate with the end of breath hold; (6) There was no contraindication of magnetic resonance examination, and the conventional T1 and T2 weighted magnetic resonance imaging scan showed normal renal morphology.
Exclusion criteria
Exclusion criteria: 1. Population with concomitant diseases that may affect the morphology or structure of the kidney, such as renal tumor, hydronephrosis, urinary tract infection, polycystic kidney, and other abdominal lesions, such as chronic pancreatitis and retroperitoneal fibrosis; 2. There were contraindications to MRI examination, such as metal implants in the body or failure to cooperate with breath holding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Group differences of fMRI indicators;Correlation between fMRI indicators and clinicopathological indicators;Diagnostic efficacy of fMRI indicators (sensitivity, specificity);Efficacy of fMRI indicators in predicting renal function progression; | — |
Countries
China
Contacts
Public ContactQin Wei
West China Hospital, Sichuan University
Outcome results
None listed