acute kidney injury
Conditions
Interventions
Low dose group (used low-dose flurbiprofen axetil (100 mg)):NA
Control group (Without flurbiprofen axeti):NA
Sponsors
the First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Inpatients undergoing surgery under general anesthesia with complete surgical anaesthesia records, hospitalization course, and examination in the Madeston and Haytech systems between January 1, 2023 and December 31, 2023; 2) Stay in hospital for at least 3 days; 3) Patients aged at least 60 years with ASA grades 1-4; 4) Patients with preoperative obesity, CKD, diabetes, hypertension, coronary artery disease, peripheral vascular disease, HB<8g/dL, and long-term use of any of ACEI/ARB.
Exclusion criteria
Exclusion criteria: 1) Acute heart failure, NYHA grade 4; 2) Long-term use of non-steroidal anti-inflammatory drugs before surgery; 3) Undergoing heart surgery; 4) Transplant surgery; 5) hypotension before surgery (admittance noninvasive cuff blood pressure 3 times the upper limit of normal); 7) Preoperative treatment in ICU; 8) Renal replacement therapy was performed before surgery; 9) Allergic to flurbiprofen axetil;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute kidney injury within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference between the highest blood urea nitrogen in 7 days after operation and the preoperative blood urea nitrogen;The difference between the highest potassium concentration within 7 days after surgery and the preoperative potassium concentration;The difference between the highest serum creatinine within 7 days after surgery and the preoperative serum creatinine ; | — |
Countries
China
Contacts
Public ContactHuang Xiongqing
An anesthesiologist at the First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed