Hip fractures
Conditions
Interventions
esmketamine group:After combined spinal-epidural anesthesia, administer a loading dose of esketamine of 0.125 mg/kg before the surgical incision, followed by a continuous infusion of 0.1 mg/kg/h until
control group:Equal dose of physiological saline
Sponsors
Shiyan Taihe Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years, regardless of gender; 2.CFS score >= 5 points; 3.Planned elective hip joint replacement surgery under combined spinal-epidural anesthesia; 4.Voluntarily signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Individuals who are allergic to the active ingredients or excipients of ketamine hydrochloride injection; 2.Patients with severe consciousness disorders or mental system diseases (such as schizophrenia, mania, bipolar disorder, psychosis, etc.) and cognitive dysfunction; 3.Individuals with a history of severe cardiovascular disease (such as congestive heart failure, severe angina attacks, or unstable angina or myocardial infarction within the past 6 months); 4.Patients with an MMSE score of < 18; 5.Patients with any contraindications for the use of ketamine hydrochloride injection: a) Patients at serious risk of elevated blood pressure or intracranial pressure; b) Patients with high intraocular pressure (glaucoma) or penetrating eye trauma; c) Patients with uncontrolled or untreated hypertension (arterial hypertension, resting systolic blood pressure exceeding 180mmHg, or resting diastolic blood pressure exceeding 100mmHg); d) Untreated or inadequately treated patients with hyperthyroidism; e) Patients with a family history of malignant hyperthermia or a high risk of malignant hyperthermia (such as strabismus, scoliosis, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS Pain Score;The time from the end of surgery to the first use of salvage analgesics after surgery;Opioid consumption within 48 hours after surgery;Incidence of intraoperative adverse events;Evaluation of Patient Efficacy Questionnaire (IPOQ Scale) 48 Hours After Surgery;Incidence of postoperative adverse events;Postoperative cognitive function ;Postoperative anxiety and depression ; | — |
Countries
China
Contacts
Public ContactLuo Xianghong
Shiyan Taihe Hospital
Outcome results
None listed