chronic periodontitis with type II diabetes mellitus
Conditions
Interventions
Experimental group:minocycline hydrochloride ointment
Control group:placebo
Sponsors
Peking University Stomatological Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-70 years old; 2. Severe periodontitis (classified as stage III-IV according to the new classification of periodontal disease in 2018); 3. The remaining teeth in the mouth (except the teeth to be removed or cannot be retained) >=15; 4. 1 week after cleaning, >=4 teeth with probing depth PD>=6mm (except for affected teeth that cannot be retained and teeth that are III degree loose as assessed by doctors); 5. One week after treatment, the BOP of total oral probe bleeding was >30%; 6.In patients diagnosed with T2DM, HbA1c was <9.0%
Exclusion criteria
Exclusion criteria: 1.Periodontal cleaning in the past 1 month or regular root scaling in the past 3 months; 2.Severe or uncontrollable diabetic complications (nephropathy stage IV or above, proliferative diabetic retinopathy, etc.); 3.Serious or uncontrollable systemic diseases other than diabetes, including diseases of the heart, liver, kidney, respiratory, blood, endocrine, nervous and psychiatric systems; 4.Pregnancy or planning pregnancy or breastfeeding; 5.Alcohol dependence; 6.Have used antibiotics in the past 3 months; 7.Tetracycline drug allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in probing depth of PD>=6mm sites at baseline from baseline to 6 months after treatment;Subgingival plaque sample; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change of PD depth at baseline PD>=5mm from baseline to 6 months after treatment;Loss of attachment CAL;Plaque index PlI;Bleeding index BI;Glycosylated hemoglobin;IL-1ßIL-17calprotectin; | — |
Countries
China
Contacts
Public ContactKaining Liu
Peking University School and Hospital of Stomatological
Outcome results
None listed