Primary hepatocellular carcinoma
Conditions
Interventions
Development dataset:None
Test dataset:None
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntary subjects with signed informed consent, demonstrating good compliance and cooperating with follow-up; 2. Patients aged over 18 years, meeting the clinical diagnostic criteria of the Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2024 version), or confirmed by histopathology or biopsy; 3. Patients with stage B-C liver cancer according to BCLC guidelines (i.e., >= 2 masses and single mass > 3cm, or more than 3 masses regardless of size, or with vascular invasion or distant metastasis regardless of size); 4. With complete biochemical examination results, medical history, and surgical records: including blood routine, the status of hepatitis B and hepatitis C, alpha-fetoprotein (AFP), abnormal prothrombin (PIVKA-II), liver function examination, and the type of hepatectomy; 5. Received preoperative systemic antitumor therapy (with or without local therapy) and underwent liver resection after the treatment; 6. With complete liver contrast enhanced CT and/or MR images before, during, and after systemic antitumor therapy (= 2 times); 7. Surgical pathological specimens of hepatocellular carcinoma were stained with HE, CD3, CD8, and CD34, and a complete pathological report was provided.
Exclusion criteria
Exclusion criteria: 1. Complicated with cholangiocarcinoma; 2. Obvious artifacts were observed in liver contrast-enhanced CT and/or MR Images; 3. The obtained surgical pathological specimens failed to meet the pathological analysis; 4. Have received any kind of systemic antitumor therapy; 5. The systemic antitumor therapy was not standardized.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival ratio,OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective response rate, ORR; | — |
Countries
China
Contacts
Public ContactTingting Xie
Peking University Shenzhen Hospital
Outcome results
None listed