Twin pregnancy
Conditions
Interventions
Aspirin group:The intervention group was given 75 mg/d, 100 mg/d, and 125 mg/d aspirin enteric-coated tablets, respectively
Aspirin control group:none
Observational trial grouping:none
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: As this study is divided into multiple clinical studies, the inclusion and exclusion criteria are listed separately: 1. Prediction of preterm birth: the predictive value of cervical parameters in the preterm birth of twins Inclusion Criteria: 1. Twin pregnancies;2. Gestational age>12 weeks; 2. Prevention of preterm birth: cervical cerclage to prevent preterm birth Inclusion criteria: (1) patients with twin pregnancies with double cashmere twin sheep; (2) Previous diagnosis of cervical insufficiency: there has been painless uterine ostium dilation leading to pregnancy loss in the second trimester; or 16 to 26 + 6 weeks of pregnancy cervical B ultrasound shows that the cervical canal is shortened < 25mm, and the uterine opening is not opened, or 16 to 24 weeks of pregnancy, physical examination or B ultrasound shows that the uterine opening is = 4cm, or 24 to 26 + 6 weeks of pregnancy, physical examination or B ultrasound shows that the uterine opening is open, one of the three can be satisfied; 3. Preeclampsia: Aspirin prevents preeclampsia Inclusion Criteria: (1) Pregnant women with twin pregnancies; (2) 8-14 weeks of pregnancy; (3) There was no abnormality in intrauterine fetal structure screening; (4) No other pregnancy complications or complications; (5) Those with complete clinical data; (6) Voluntarily join the study and sign the informed consent form; 4. Occurrence and prognosis of complications specific to monochorionic twin pregnancy Inclusion criteria: (1) monochorionic twin pregnancies, including assisted reproduction and natural conception; (2) Leave ultrasound image data in our hospital and deliver in our hospital; (3) The control group was all pregnant women with twin pregnancies without complications.
Exclusion criteria
Exclusion criteria: As this study is divided into multiple clinical studies, the inclusion and exclusion criteria are listed separately: 1. Prediction of preterm birth: the predictive value of cervical parameters in the preterm birth of twins Exclusion criteria: 1. Signs of labor (regular contractions with cervical shortening of more than 12 hours) 2. Patients with serious comorbidities and complications (intrauterine infection, severe preeclampsia, placental abruption, twin transfusion syndrome, severe medical and surgical diseases, etc.) 3. Cervical cerclage 4. Combined fetal chromosomal abnormalities or congenital developmental malformations 5. Premature rupture of membranes before diagnosis 6. Stillbirth of one of the twins was found before diagnosis 7. Selective fetal reduction surgery was performed in the first trimester 2. Prevention of preterm birth: cervical cerclage to prevent preterm birth Exclusion criteria: (1) fetal malformations requiring induction of labor; (2) Patients with medical preterm birth due to twin complications, such as preeclampsia, placental abruption, etc.; (3) Premature rupture of membranes, suspected intrauterine cavity infection, etc., patients who cannot undergo cervical cerclage; (4) Refusal to participate in the study. 3. Preeclampsia: Aspirin prevents preeclampsia Exclusion Criteria: (1) Pregnant women with singleton pregnancies; (2) Those who suffer from diabetes, hypertension, kidney disease, cardiovascular disease, and coagulation dysfunction before pregnancy. (3) Incomplete clinical data. 4. Exclusion criteria for the occurrence and prognosis of monochorionic twin pregnancy specific complications: (1) patients with co-infection (genital tract, intrauterine infection); (2) Patients with incomplete data and unable to obtain complete data by telephone follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of preeclampsia;Incidence of preterm birth before 34 weeks;Maternal metabolic endocrine index and fetal growth and development index;Incidence of special complications in monochorionic pregnancies;cervical length;Width of the internal cervical orifice;Cervical elasticity parameters;Coagulation function;B-ultrasound indexes of growth and development at each gestational week;Fetal and maternal complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of preterm birth before 32 weeks;Incidence of preterm birth before 28 weeks;prolonged pregnancy week; | — |
Countries
China
Contacts
Public ContactZhang Weishe
Xiangya Hospital, Central South University
Outcome results
None listed