Adolescent Obsessive-Compulsive Disorder
Conditions
Interventions
Healthy Control Group:None
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: Drug-Free Adolescent Obsessive-Compulsive Disorder Group: (1) Meet the DSM-5 diagnostic criteria for OCD through structured clinical interview (SCID-V); (2) Age between 10 to 18 years old; (3) Patients voluntarily participate in the study, have obtained family consent, and have signed an informed consent form; (4) Understand written language and are able to complete questionnaires; (5) Score of =16 on the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS); (6) Han ethnicity, right-handed; (7) Have not taken any medication for OCD for at least 8 weeks prior to enrollment. Healthy Control Group: (1) Age between 10 to 18 years old; (2) Voluntarily participate in the study, have obtained family consent, and have signed an informed consent form; (3) Understand written language and are able to complete questionnaires; (4) Han ethnicity, right-handed.
Exclusion criteria
Exclusion criteria: Drug-Free Adolescent Obsessive-Compulsive Disorder Group: (1) History of substance dependence; history of mental disorders that meet the SCID Axis I diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (3) Contraindications for MRI; (4) Pregnant or breastfeeding patients; (5) Family history or personal history of epilepsy. Healthy Control Group: (1) History of substance dependence; history of any mental disorders that meet the SCID Axis I or II diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) History of loss of consciousness; (3) Positive family history of mental illness in two generations and three degrees; (4) History of taking antipsychotic or antidepressant medications; use of benzodiazepines or other central nervous system affecting drugs within one month before MRI; continuous medication treatment within the past 6 months; (5) Uncooperative in testing or unable to effectively complete tests; (6) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (7) Contraindications for MRI; (8) Pregnant or breastfeeding; (9) Color blindness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Children's Yale-Brown Obsessive-Compulsive Scale;functional magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Swanson, Nolan, and Pelham, Version IV;Yale Global Tic Severity Scale;Family Accommodation Scale – Interviewer Rated;Obsessive-Compulsive Inventory - Child Version;Children's Depression Inventory;Spence Children's Anxiety Scale;The Adolescent Sleep Disturbance Questionnaire;Raven’s Progressive Matrices;Adolescent Self-Rating Life Events Check List; Eysenck Personality Questionnaire;Cognitive Scale; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed