tonsillectomy and adenoidectomy surgery
Conditions
Interventions
A:Nalbuphine intravenous 0.1mg/kg before induction of anesthesia and sugammadex 2mg/kg after surgery
B:Nalbuphine intravenous 0.1mg/kg before induction of anesthesia and neostigmine 50ug/kg + atropine 0.02mg/kg after surgery
C:Before induction of anesthesia, trantranasal dexmedetomidine 1 ug /kg after surgery
Sponsors
Children's Hospital of Shanghai
Eligibility
Sex/Gender
All
Age
3 Years to 9 Years
Inclusion criteria
Inclusion criteria: ASA grades I-II, 3-9 years old, with tonsil adenoidectomy under elective general anesthesia.
Exclusion criteria
Exclusion criteria: Allergy to drugs such as nalbuphine, dexmedetomidine used in this study; allergic to any sedation, analgesia, antiemetic and antiitching drugs taken 24 h before surgery; respiratory inhibitory disease or asthma, accompanied by respiratory, cardiovascular, and neurological diseases, moderate to severe hepatic and renal dysfunction; and received any other test drugs within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| emergence agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pain;The incidence of postoperative bradycardia;Extubation time;recovery period;Parent satisfaction;PONV; postoperative respiratory depression ; | — |
Countries
China
Contacts
Public ContactChange Zhu
Children's Hospital of Shanghai
Outcome results
None listed