Postoperative sleep disorders
Conditions
Interventions
Experimental group:Anesthesia induction options: patients with propofol 1.5 mg-kg-1, sufentanil 0.5 µg-kg-1, and esketamine 0.4 mg-kg-1. Sedation and analgesia were maintained with propofol 2-10 mg/kg
Control subjects:Anesthesia induction was selected by propofol 1.5 mg-kg-1 + sufentanil 0.5 µg-kg-1 using propofol 5-10 mg-kg-1-h-1 and remifentanil 5-10 µg.kg-1.h-1 pumping for maintenance of sedatio
Sponsors
Liaoning Cancer Hospital & Institute
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. No contraindications to anesthesia, no serious underlying diseases before surgery, no heart, liver and kidney dysfunction, etc. 2. Female patients who intend to undergo breast cancer surgery, including total mastectomy, partial mastectomy, breast-conserving surgery, and breast reconstruction surgery. 3. Age 18-55 years old, ASAI.~II 4. Preoperative SDS score < 50, SAS score < 50 5. No history of mental illness (such as depression, anxiety, schizophrenia, etc.) or neurological disease (such as epilepsy, Parkinson's disease, etc.), and currently not receiving any medication that may affect the function of the central nervous system. 6. No history of long-term use of psychoactive drugs (such as antidepressants, antipsychotics, benzodiazepines, etc.) or narcotic drug addiction. 7. No history of chronic sleep disorders, such as insomnia, sleep apnea syndrome, etc., and have not received any form of sleep therapy in the last month. 8. No serious cardiovascular, respiratory, liver and kidney dysfunction, such as heart failure, severe chronic obstructive pulmonary disease, end-stage renal disease, etc. 9. No recent (past 6 months) history of major surgical surgery or trauma. 10. Patients with early-stage or intermediate-stage breast cancer without distant metastasis. 11. Patient voluntarily signed informed consent, indicating that he understands the study content, possible risks and benefits, and is willing to participate in the entire study process.
Exclusion criteria
Exclusion criteria: 1. Any patient with contraindications to surgery or anesthesia. 2. Patients at risk for the use of esketamine (including hypertension and other cardiovascular diseases, glaucoma, pregnant or lactating women) 3. Patients with hyperthyroidism (hyperthyroidism). 4. Patients who are unwilling or unable to cooperate in completing the requirements of the study before or after surgery. 5. Patients who have received radiotherapy or chemotherapy that may affect the effect of anesthesia or study intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative sleep quality; | — |
Countries
China
Contacts
Public ContactHuang Zeqing
Liaoning Cancer Hospital & Institute
Outcome results
None listed