Alzheimer's Disease
Conditions
Interventions
Observation group:Drug treatment: Donepezil hydrochloride tablet 10mg once/night oral drug treatment
Remote ischemic adaptation training (RIC) : The patient was placed in a supine or semi-seated position, the upper limbs and the heart were at the same level as possible, the two cuffs of the training
Control group:Drug treatment: Donepezil hydrochloride tablet 10mg once/night oral drug treatment
Sham remote ischemic adaptation training (RIC-sham) : The patient was placed in a supine or semi-seated position, the upper limbs and the heart were at the same level as possible, the two cuffs of the
Sponsors
Beijing Luhe Hospital, Capital Medical University , Beijing, China
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are as follows: (1) Diagnostic criteria for mAD patients: Meet the 2011 core clinical criteria of the National Institute on Aging and Alzheimer's Association (NIA-AA) "Probable AD Dementia" [6]. History: Episodic memory impairment occurred mainly in the early stage, and the course of the disease was more than 6 months. Scores of mini-mental state examination (MMSE) range from 2l to 26 points (junior high school education and above). ischemic scale of hachinski (HIS)=4 points. activities of daily living (ADL)>26 points, hamilton anxiety scale (HAMA) (14 points) <14 points, Hamilton depressive scale (HAMD) (17 items) score <17. CT or MRI scans of the head support the diagnostic criteria for AD and exclude other obvious disorders such as severe anxiety and depression that could explain the memory impairment); (2) Age 50-85 years old, male or female; (3) Junior high school or above; (4) There are fixed caregivers, who need to assist patients to participate in the whole process of the study; The guardian is willing to allow the elderly to participate.
Exclusion criteria
Exclusion criteria: Contraindications for ischemic conditions (e.g., severe soft tissue injury, fracture, and bilateral upper limb peripheral vascular disease); Hemodynamic instability (i.e., systolic blood pressure >180mmHg, diastolic blood pressure >110mmHg, heart rate 100 beats/min, percutaneous oxygen saturation =92%, or body temperature =38.5°C); (3) Life expectancy =1 year; (4) For those with circulatory, respiratory, digestive, blood system diseases or malignant tumors with poor tolerance to treatment; (5) Coagulation dysfunction or active bleeding; (6) with a combination of inflammation or drugs that affect the level of inflammatory factors; ? Pregnant or breastfeeding; (8) Exclusion criteria include cerebrovascular disease (cerebral infarction, cerebral hemorrhage), vascular dementia, small cerebral vascular disease, thyroid dysfunction, epilepsy, Parkinson's disease, malnutrition, long-term diarrhea, carbon monoxide poisoning, craniocerebral trauma, alcoholism and other serious neurological diseases, mental diseases, serious physical diseases; 9. Participate in another ongoing clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Simple Mental State Examination Scale (MMSE);Montreal Cognitive Assessment Scale (MOCA);Clinical Dementia Rating Scale (CDR);Daily Living Ability Scale (ADL);Hamilton Anxiety Scale (HAMA);Hamilton Depression Scale (HAMD-17); | — |
Secondary
| Measure | Time frame |
|---|---|
| Glial fibrillary acidic protein;pTau217pTau181pTau231;Neurofilament light chain protein;Aß40;Aß42;Aß42/Aß40; | — |
Countries
China
Contacts
Public ContactXin Huang
Department of Neurology , Beijing Luhe Hospital, Capital Medical University , Beijing, China
Outcome results
None listed