Rapid Eye Movement Sleep Behavior Disorder
Conditions
Interventions
Patients with REM sleep behavior disorder:NA
Patients with a-synucleinopathies:NA
Control group:NA
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with REM sleep behavior disorder: age >= 40 years; meet the diagnostic criteria of REM sleep behavior disorder in ICSD-3. 2. Patients with a-synucleinopathies: age >= 40 years; age and gender matching the REM sleep behavior disorder group; clinically diagnosed a-synucleinopathies (including Parkinson's disease, Lewy body dementia, and multiple system atrophy). 3. Control : age >= 40 years; age-sex matched to the REM sleep behavior disorder group.
Exclusion criteria
Exclusion criteria: 1. Patients with rapid eye movement sleep behavior disorder excluded: narcolepsy; epilepsy; neurodegenerative disease; major physical illness. 2. Patients with alpha-synucleinopathy excluded: narcolepsy; epilepsy; major physical illness. 3. Controls excluded: diagnostic criteria for REM sleep behavior disorder in ICSD-3; narcolepsy; epilepsy; neurodegenerative disease; major physical illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSG Indicators;non-motor symptoms;motor symptoms;General Information;MRI scan of the brain;RBD questionnaire assessment;PET/CT;Artificial intelligence digital phenotype;Assessment of neurocognitive function;Computer test;MCI/PD/DLB/MSA Clinical diagnostic assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rest-activity mode;Psychiatry Clinical Interview;Sleep Clinical Interview;Family diagram; | — |
Countries
China
Contacts
Public ContactJihui Zhang
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed