Breast Cancer
Conditions
Interventions
Breast cancer treated with CDK4/6 inhibitor:None
Ordinary breast cancer patients:None
Sponsors
Breast Surgery of the First Hospital of China Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1: Female patients aged 18 years or older and 85 years or younger. 2: For early, local progress or advanced breast cancer confirmed by puncture or surgery pathology, imaging has clear and measurable lesions.
Exclusion criteria
Exclusion criteria: 1: Life expectancy and medication duration are less than 3 months; 2: Suffering from severe uncontrolled systemic diseases, or evidence or medical history of visceral crisis, central nervous system metastasis; (Visceral crisis is defined as several organ dysfunction confirmed by symptoms, signs, laboratory tests, and rapid disease progression. Visceral crisis does not simply refer to the presence of visceral metastasis, but rather to critical visceral conditions that require rapid and effective treatment to control disease progression, especially when the opportunity for chemotherapy is lost after progression.); 3: Suffering from serious accompanying diseases or other accompanying diseases that may interfere with the study, or any other circumstances that the researcher deems unsuitable for the patient to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival;Expression of DKK1;Expression of CDK6; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Expression of CD3;Expression of CD8;Expression of CD56;Expression of CD68;Expression of FOXP3;Expression of PD1;Expression of PD-L1;Expression of p-RB; | — |
Countries
China
Contacts
Public ContactBo Chen
The First Hospital of China Medical University
Outcome results
None listed