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A Multicenter Prospective Cohort Study Based on Metabolomics on the Timing of Surgery and Changes in Bile Composition in Patients with Distal Malignant Obstructive Jaundice after Preoperative Biliary Drainage

A Multicenter Prospective Cohort Study Based on Metabolomics on the Timing of Surgery and Changes in Bile Composition in Patients with Distal Malignant Obstructive Jaundice after Preoperative Biliary Drainage

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400092203
Enrollment
Unknown
Registered
2024-11-12
Start date
2024-12-01
Completion date
Unknown
Last updated
2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malignant obstructive jaundice

Interventions

Group B: Complication group:None
Group A: Non-complication group:None

Sponsors

General Hospital of Western Theater Command
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1). Age between 18 and 70 years; (2). Presence of symptoms of obstructive jaundice (such as jaundice of the skin, jaundice of the sclera, and dark yellow urine), with serum total bilirubin > 200 µmol/L upon hospital admission; (3).Preoperative imaging and clinical diagnosis suggest distal malignant biliary obstruction; (4).Underwent preoperative biliary drainage at the participating hospital of this study; (5). Underwent curative surgical treatment at the participating hospital of this study; (6). Informed consent obtained from the patient and their family, with voluntary participation in the study.

Exclusion criteria

Exclusion criteria: (1). Patients with surgical contraindications or those unable to undergo curative surgery for any reason; (2).Patients who only receive palliative surgical treatment; (3). Postoperative pathological diagnosis indicating benign disease; (4).Incomplete medical records; (5).Presence of diabetes, metabolic syndrome, or other severe chronic systemic diseases; (6).Prior to inclusion, patients who have undergone procedures such as biliary imaging, biliary surgery, bile duct or gallbladder puncture and drainage, biliary stent placement, or nasobiliary drainage.

Design outcomes

Primary

MeasureTime frame
Bile acid metabolomics;

Secondary

MeasureTime frame
General situation;Intraoperative situation;Pathological data;

Countries

China

Contacts

Public ContactDai Ruiwu

General Hospital of Western Theater Command

dairuiwu@swjtu.edu.cn+86 181 1661 3501

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026