Incidence of intraoperative hypotension and postoperative memory, sleep quality and anti-anxiety
Conditions
Interventions
Cyclopofol Group:Cyclopofol (0.4-0.6)mg/kg was injected intravenously for about 30 seconds. If there is a kinetic reaction during the examination, add cyclopofol (0.15-0.2)mg/kg.
Propofol Group:Propofol (1-3 mg/kg) was administered intravenously for about 30 seconds. If kinetic reactions occur during the examination, propofol (0.5-1)mg/kg should be added.
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 18 years old < age <80 years old; ASA Class I - III (2) Male and female gender is not limited; (3) Choose to perform painless gastroenteroscopy and treat hospitalized patients (4) Before the trial, patients should have a detailed understanding of the nature, significance, possible benefits, possible inconveniences and potential dangers of the trial, understand the research procedure and sign the informed consent in person.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women and those who have a birth plan within 3 months; (2) Patients with obvious respiratory and circulatory dysfunction and abnormal liver and kidney function before operation; (3) Patients with severe neuropsychiatric diseases; (4) Those who are allergic or contraindicated to drugs and their components such as cyclopofol or propofol; (5) long-term (more than 3 months) taking antidepressants, anti-anxiety drugs or other psychotropic drugs; (6) Inability to understand or refusal to complete the questionnaire; (7) Patients who are unable to obtain informed consent, or who are considered inappropriate by the investigator to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence of intraoperative hypotension (systolic blood pressure less than 90mmHg or blood pressure reduction greater than 30% of the base blood pressure).; | — |
Secondary
| Measure | Time frame |
|---|---|
| The adverse reactions during anesthesia;Time of recovery from anesthesia;Adverse reactions during recovery;Sleep quality 1 day after surgery;Memory level 1 day after surgery;Occurrence of anxiety 1 day after surgery;Patient and endoscopist satisfaction scores; | — |
Countries
China
Contacts
Public ContactWang Bin
Qingdao Municipal Hospital
Outcome results
None listed