Rheumatoid arthritis
Conditions
Interventions
Clinical remission group:None
Low disease activity group:None
Sponsors
Meishan People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 65 years; 2. Meets the 2010 American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) classification criteria for RA diagnosis; 3. Has undergone at least 3 months of treatment with one or more conventional synthetic disease-modifying antirheumatic drugs (CSDMARDS) combined with standard-dose TNF inhibitors (tumor necrosis factor inhibitors, TNFi), with an improvement in SDAI = 50% after treatment.
Exclusion criteria
Exclusion criteria: 1. Participation in other drug observer studies within the last 6 months. 2. Use of oral glucocorticoids during the screening period, or glucocorticoid injections into the joint cavity, intramuscularly, or intravenously within the past month. 3. History of active peptic ulcer disease. 4. Patients with significant hematologic disorders and abnormal lab test results (WBC < 4 × 10^9/L or PLT < 100 × 10^9/L). 5. ALT = 2 × ULN, AST = 2 × ULN, GFR = 40 ml/min. 6. History of acute or chronic infections (including, but not limited to, viral hepatitis, herpes zoster virus, tuberculosis, etc.). 7. History of malignant tumors, decompensated heart failure or severe hypertension, epilepsy, and other neurological disorders. 8. History of alcoholism within the past 2 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SDAI score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event monitoring; | — |
Countries
China
Contacts
Public ContactZehui Liao
Meishan People's Hospital
Outcome results
None listed