shivering
Conditions
Interventions
The esketamine group:Intravenous Esketamine 0.25mg/kg
The dexmedetomidine group:Intravenous pump infusion of dexmedetomidine 0.5 ug/kg
Sponsors
Hangzhou Women's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.? 18 years old or above; 2.? ASA physical status 1 or 2; 3.? gestation >= 36 weeks; 4.? singleton pregnancy; 5.? elective cesarean section; 6.? shivering after anesthesia.
Exclusion criteria
Exclusion criteria: 1.?Emergency cesarean section; 2.?General anesthesia; 3.?History of hypertension, preeclampsia or eclampsia; 4.?Heart, renal or hepatic disease; 5.?Confirmed depression or unstable mental disorder; 6.?weight over 120 kg; 7.?administration of blood products during surgery, or the incidence of major surgical complications; 8.?Hypersensitivity to any of the study drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-40 score 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| the onset time of drug;shivering scale;Whether the patient has a shiver again;The degree of sedation;body temperature;Highest level of anesthesia;Duration of surgery;intraoperative intravenous infusion volume;dose of vasopressor;Apgar scores;patient satisfaction;intravenous fentanyl;Blood loss;Adverse reactions: nausea, vomiting, hypertension, hypotension, bradycardia, tachycardia, nystagmus, hallucination;Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure; | — |
Countries
China
Contacts
Public ContactMen Xin
Hangzhou Women's Hospital
Outcome results
None listed