Rhabdomyolysis
Conditions
Interventions
CRRT+HA group:Based on the CRRT group, the hemoperfusion device HA380 (Jianfan Biology, China) was connected in series after the filter for 10 hours.
CRRT group:The dialyzer uses AN69-ST150 membrane (Baxter Kinbao, USA), and the dialysis mode is CVVHDF. It is diluted and infused with commercial calcium-containing hemofiltration basic replacement fl
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.The patient meets the RM diagnostic criteria (creatine kinase > 1000 IU/L or more than 5 times the upper limit of normal, accompanied by a significant increase in serum myoglobin), and the patient's creatine kinase is >=5000IU/L, and myoglobin is >=3000ng/mL; 2. Diagnostic criteria for AKI: An increase of more than 26.5 µmol/L in serum creatinine within 48 hours or more than 50% of the baseline value within 7 days; Or urine output is less than 0.5 mL/ (kg·h) for more than 6 hours; 3. The clinical assessment indicates that the patient's condition requires continuous renal replacement therapy, and the patient or their family is willing to undergo CRRT or CRRT+HA treatment and sign the informed consent form. 4. RM patients with AKI who were admitted to the ICU.
Exclusion criteria
Exclusion criteria: 1. Those who have already received other blood purification treatment modes or plan to receive other blood purification treatment modes before enrollment; 2. The cause of the patient's rhabdomyolysis is myositis or myopathy. 3. Have a history of chronic renal insufficiency; 4. Pregnant women and patients who have undergone organ transplants; 5. Patients or their family members who are unwilling to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myoglobin plasma clearance ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Creatine kinase plasma clearance ;Haemodynamics;Recovery of renal function;All-cause mortality;APACHE II score and SOFA score;Length of hospital stay;Plasma Clearance Efficiency of Myoglobin and Creatine Kinase by Blood Adsorption; | — |
Countries
China
Contacts
Public ContactLing Zhang
West China Hospital of Sichuan University
Outcome results
None listed