Invasive Pulmonary Fungal Disease
Conditions
Interventions
Invasive Pulmonary Fungal Disease Group:None.
Healthy control group:None.
Viral Group:None.
Bacterial group:None.
Sponsors
The First Affiliated Hospital ,Guangzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The enrollment criteria for the fungal group were as follows: 1) hospitalized patients; 2) Age= 18 years old; 3) Patients with clinically diagnosed or confirmed invasive pulmonary mycosis according to the guidelines for the diagnosis and treatment of invasive fungal diseases (refer to the 2019 EORTC/MSG guidelines criteria). Exclusion criteria for patients: 1) HIV-positive; 2) pregnant and lactating patients; 3) Those who have participated in any interventional clinical study in the 3 months prior to enrollment; 4) Patients with incomplete clinical data; 5) Those who are considered unsuitable for enrollment by the investigator with other conditions; 6) Those who do not sign the informed consent form. Viral Inclusion Criteria: 1) Hospitalized patients; 2) Age= 18 years old; 3) Meet the diagnostic criteria for viral pneumonia. Exclusion Criteria: 1) Long-term use of hormones or/and immunosuppressants due to underlying diseases; 2) Respiratory failure or shock caused by underlying lung disease, acute pulmonary embolism, cardiogenic disease, large airway obstruction and other factors; 3) Severe lack of clinical information. The clinical information of patients with viral pneumonia was collected, such as underlying diseases, laboratory tests, imaging data, etiological detection and treatment measures, such as the use of antiviral drugs, glucocorticoids and other anti-inflammatory drugs (such as IL-6 receptor antagonists, JAK inhibitors, etc.), and their disease process and clinical outcomes were recorded, such as the duration of mechanical ventilation, length of ICU stay, 30-day death, secondary bacterial infection, direct cause of death, etc. The enrollment criteria for the bacteriological group are as follows: 1) age= 18 years old; 2) Chest X-ray or CT showing new or progressive infiltrates, consolidation or ground-glass opacities, plus 2 or more of the following 3 clinical symptoms, can establish a clinical diagnosis: a) fever, body temperature > 38°C; b) purulent airway secretions; c) Peripheral blood white blood cell count > 10×109/L or <4×109/L. 3) Have a qualified basis for bacterial pathogenic diagnosis. 4) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Those who are unable to understand and implement the investigation plan. 2) Active tuberculosis. 3) Immunodeficiency patients, long-term use of immunosuppressants or hormones. 4) HIV patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T-cell;Circulating Free DNA;TAFC;Sphingolipid Metabolites; | — |
Countries
China
Contacts
Public ContactFeng Ye
The First Affiliated Hospital ,Guangzhou Medical University
Outcome results
None listed