Infection
Conditions
Interventions
Loading group:The first dose was given a loading dose (1.5 times the maintenance dose), followed by a regular dose of 15mg/Kg q8h or q12h or q24h, the specific frequency adjusted according to creatini
Continuous infusion group:The initial dose of 20mg/Kg was given continuously after surgery, followed by a maintenance infusion of 15-40mg/Kg, depending on creatinine clearance, for 14 days.
Sponsors
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Hospitalization at the Research Center Hospital from January 1, 2025 to December 31, 2027 2. Use vancomycin for empirical or targeted treatment 3. Age =18 years old 4. Voluntarily (or legal agent agrees) to participate in the study and sign the informed consent
Exclusion criteria
Exclusion criteria: 1. Vancomycin was used within 3 days before enrollment 2. Pregnancy or breastfeeding 3. Patients with deteriorating renal function: patients with creatinine rising =10µmol/L per day 4. Clinical investigator participating in another investigational drug or investigational device within 3 months prior to the trial; 5. The subject is unable or unwilling to comply with study specific procedures and restrictions; 6. The investigator judged that he could not complete the study or it was not appropriate to participate in the study (expected to die within 72 hours, the patient refused active treatment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of Vancomycin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Creatinine; | — |
Countries
China
Contacts
Public ContactHuang Yanxia
Ruijin Hospital
Outcome results
None listed