Application and Mechanism of Neural Circuit Regulation under Cognitive Task Load in Improving Memory Function in Amnestic Mild Cognitive Impairment Patients with Different Tongue Coatings

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400092126

Enrollment

Unknown

Registered

2024-11-11

Start date

2024-11-30

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

amnestic mild cognitive impairment

Interventions

thin coating, task training and paired stimulation:paired stimuli in the prefrontal-posterior parietal circuits, memory training

thin coating, task training and single-target stimulation:single-target stimuli in the prefrontal cortex, memory training

thick coating, task training and paired stimulation:paired stimuli in the prefrontal-posterior parietal circuits, memory training

thick coating, task training and single-target stimulation:single-target stimuli in the prefrontal cortex, memory training

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) a diagnosis of aMCI, no history of medications for memory improvement; (2) age ranging from 50 to 80 years old, no gender limits, right-handed; (3) complaints about memory decline, impaired long-delayed recall [1 standard deviation below age-adjusted norms for Auditory Verbal Learning Test Fifth Trial (AVLT_N5) score]; (4) education >= 6 years; (5) Understand and agree to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) no coatings; (2) Cancer, severe cardiac, hepatic, renal, circulatory, or infectious dysfunction; (3) History of neurological disease which could cause dementia, such as cerebrovascular disease and Parkinson's disease; (4) History of anxiety, depression, schizophrenia and other mental illness; (5) Severe hearing or visual impairment, making it impossible to complete the full set of neuropsychological assessment scales; (6) Contraindications to MRI (e.g., pacemakers, heart stents, artificial heart valves, fixation plates after fracture surgery, etc.).

Design outcomes

Primary

Measure	Time frame
Auditory Verbal Learning Test Fifth Trial ;	—

Secondary

Measure	Time frame
Neuropsychological evaluations;Magnetic Resonance Imaging;Neuroelectrophysiological indicators;Mood test;Daily living ability test;TCM Syndrome Scale;	—

Countries

China

Contacts

Public ContactJie-Ma

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

drmajie@126.com+86 137 0182 0662

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026