Parkinson's disease
Conditions
Interventions
Test group (surgical group):deep brain stimulation
Control group (non-surgical group):Anti-PD-related drugs
Sponsors
The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.It meets the western medicine diagnostic criteria of primary Parkinson's disease. 2. Age is from 40 to 75 years old. 3.The course of the disease was more than 5 years, he had been treated with levodopa drugs and had good efficacy, and the improvement rate of dopamine shock test symptoms was 30%. 4.Hoehn-Yahr Parkinson's disease classification standard stage 2.5-4 5.The efficacy of drug treatment was significantly decreased, and intolerable exercise complications and drug side effects appeared. 6.The patient or the patient's legal representative was informed and agreed to perform the DBS surgery. 7.It meets the diagnostic criteria of geriatric fibrillation syndrome in the Diagnosis and Efficacy Evaluation Index of Traditional Chinese Medicine.
Exclusion criteria
Exclusion criteria: 1.Various secondary Parkinson's syndrome, familial inherited Parkinson's syndrome, and Parkinson's superposition syndrome. 2.Patients with other serious neurological diseases, loss of consciousness, dementia (simple intelligent state examination (MMSE) 24 points), mental disorders and other patients unable to communicate; 3.Having the serious underlying disease who cannot tolerate the operation or affect the postoperative survival period; 4.Failure to comply with the trial schedule.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| International Movement Disorders Association Unified Parkinson's Disease Rating Scale Part III; | — |
Secondary
| Measure | Time frame |
|---|---|
| Equivalent levodopa drug dosage;DBS setup parameter;SCOUP-AUT;Parkinson’s Disease Questionnaire - 39;Local Field Potential,LFP;Gait monitoring;International Movement Disorders Association Unified Parkinson's Disease Rating Scale Part IV;Purdue nail board;HAMD;Hamilton Depression Scale,HAMD;Parkinson’s Disease Sleep Scale; | — |
Countries
China
Contacts
Public ContactJun Li
The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Outcome results
None listed