chronic obstructive pulmonary disease
Conditions
Interventions
Healthy control group:none
Sponsors
Hebei Petro China Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Meeting the diagnostic criteria for COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD, 2023 update): Patients with corresponding clinical symptoms who have a post-bronchodilator forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio of <70%; Age =18 years; Voluntary participation in this clinical study
Exclusion criteria
Exclusion criteria: Exclusion criteria for all enrolled participants include the presence of any of the following comorbidities or complications: History of acute exacerbations of chronic obstructive pulmonary disease (COPD) within three months prior to enrollment; Presence of other respiratory diseases, such as active pulmonary tuberculosis, bronchiectasis, pulmonary embolism, interstitial lung disease, etc.; Coexistence of severe heart, brain, liver, kidney diseases, or malignant tumors; Current use of oral glucocorticoids and theophylline medications; Incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of acute exacerbations within 1 year;Cumulative survival rate within 3 years;Time of the first acute exacerbation; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-17;MUC5AC;MUC5B;IL-1ß;IL-6;IL-10;TNF-a;FEV1;FVC;FEV1/FVC;DLCO;6MWD;COPD assessment test;modified Medical Research Council; | — |
Countries
China
Contacts
Public ContactJiao Ma
Hebei Petro China Central Hospital
Outcome results
None listed