Skull defects, hemorrhagic brain diseases, malignant intracranial tumors, traumatic intracranial hematomas
Conditions
Interventions
Skull Defect Group:None
Skull Integrity Group:Anesthesia drug
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 18 to 75 undergoing cranioplasty or decompressive craniectomy, any gender. (2) Those willing to use effective contraception during the study, and women of childbearing age must have a negative pregnancy test. (3) Signing the informed consent form and agreeing to participate in all visits, examinations, and treatments as required by the study protocol.
Exclusion criteria
Exclusion criteria: 1. Known eye pathology or history of optic nerve damage; 2.(2) Unable to access the ultrasound window; 3.(3) Clinical or radiological suspicion of cerebral venous thrombosis or vascular spasm; 4.(4) Patients with severe valvular heart disease or diagnosed with refractory atrial fibrillation; 5.(5) Patients with severe respiratory, circulatory, hepatic, or renal insufficiency who cannot tolerate treatment and examination; 6.(6) Severe febrile illness or viral disease in the past 12 weeks; 7.(7) Pregnant or lactating women; 8.(8) Participants who have participated in or are participating in this study or other clinical trials in the 12 weeks prior to enrollment; 9.(9) Other conditions deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameter, pulsatility index, straight sinus blood flow velocit; | — |
Countries
China
Contacts
Public ContactMokai
Zhujiang Hospital of Southern Medical University
Outcome results
None listed