Restlessness
Conditions
Interventions
A group:Remifentanil was infused at 1/8 of the basal rate until 10 min after extubation
B group:Remifentanil was infused at 1/4 of the basal rate until 10 min after extubation
C group:Remifentanil was infused at 1/2 of the basal rate until 10 min after extubation
D group:Remifentanil infusion was stopped at the end of operation and normal saline was infused at 1/2 of the basal rate until 10min after extubation
Sponsors
The Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Thoracoscopic lobectomy was performed for preoperative diagnosis of pulmonary space occupying or pulmonary nodules 2. A history of hypertension was clearly diagnosed in the past 3. Age 18-80 years old 4. BMI 18-30 kg/m2 5. ASA Grade I-II 6. Those who voluntarily join and sign informed consent after fully explaining the contents of clinical trials
Exclusion criteria
Exclusion criteria: 1. Mental or neurological disorders 2. Any previous mental illness 3. Visual, auditory, language or other obstacles to communication and evaluation 4. Use analgesics or receive psychotropic drugs 5. Study related drug allergies 6. Opioid contraindications 7. Refuse to use postoperative analgesia 8. Skin infection or systemic infection near the puncture site, etc. 9. Patients with severe pulmonary hypertension, arrhythmia or cardiac insufficiency; Patients with liver and kidney function; Or increased intracranial pressure or intraocular pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Riker sedation and restlessness score;Restlessness score in Allen Su period;RPP and PRQ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS) pain score;The first PCA time and the number of analgesic pump presses within 48 hours after surgery;Accumulated consumption of postoperative analgesics and frequency of remedial analgesia;Postoperative complications such as dizziness, nausea, vomiting, respiratory depression, and skin itching;AICU stay time and postoperative hospitalization days of subjects;Spontaneous breathing recovery time, Allen Su time, extubation time;Cough during extubation; | — |
Countries
China
Contacts
Public ContactLi Rui
The Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed