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Improvement of postprandial blood glucose in people with impaired glucose tolerance by different dietary fiber supplements based on CGM: a N-of-1 trial.

Improvement of postprandial blood glucose in people with impaired glucose tolerance by different dietary fiber supplements based on CGM: a N-of-1 trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400092056
Enrollment
Unknown
Registered
2024-11-08
Start date
2024-11-11
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Isolated impaired glucose tolerance

Interventions

Intervention group 1 :Konjac dietary fiber first,then Guar gum dietary fiber
Intervention group 2:Guar gum dietary fiber first,then Konjac dietary fiber

Sponsors

School of public health, WuHan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Men or women aged 20-40; 2.BMI =18 kg/m2; 3. Impaired glucose tolerance (IGT) is defined as meeting any of the following criteria: ? Fasting blood glucose <6.1 mmol/L and 2-hour plasma glucose after an oral glucose tolerance test (OGTT) with 75g glucose of =7.8 mmol/L but <11.1 mmol/L; ? Fasting blood glucose <6.1 mmol/L and hemoglobin A1c (HbA1c) of =5.7% but <6.5%. 4. Agree to participate in this project and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Have consumed fiber-based dietary supplements within the past three months; 2. Be taking hypoglycemic medications; 3. Be heavy drinkers (with an average of more than five times of drinking per week, more than five bottles of beer or more than two ounces of Baijiu each time); 4. Have undergone drug or surgical weight loss within the past three months; 5. Have one of the following diseases: diabetes; cardiovascular diseases; gastrointestinal diseases (except for mild chronic superficial gastritis); cancer; thyroid diseases; liver diseases; other serious acute or chronic diseases; 6. Have infectious diseases such as tuberculosis and AIDS; 7. Be subjects under severe trauma, surgery or other stressful circumstances; 8. Be pregnant or lactating or planning to become pregnant.

Design outcomes

Primary

MeasureTime frame
Fasting blood glucose;Postprandial blood sugar level after 10 minutes;Postprandial blood sugar level after 20 minutes;Postprandial blood sugar level after 30 minutes;Postprandial blood sugar level after 60 minutes;Postprandial blood sugar level after 120 minutes;Postprandial blood sugar level after 150 minutes;Postprandial blood sugar level after 180 minutes;—

Secondary

MeasureTime frame
GLP-1;GIP;CCK;GCG;Peptide YY,PYY;FGF21;Amylin;alpha amylase;MBG;TIR;TAR;TBR;CV; CONGA; MAGE;Subjective appetite assessment;insulin;—

Countries

China

Contacts

Public ContactZhao Lina; Dong zhenhua

School of public health, WuHan University

zhaoln@whu.edu.cn+86 133 2642 2823

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026