postoperative sleep disorder
Conditions
Interventions
control group:normal saline (i.v.) after the induction of anesthesia
esketamine group:0.3mg/kg esketamine (i.v.) after the induction of anesthesia
Sponsors
The Third Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1, 18 to 65 years 2, ASA grade I ~ III level of patients 3, Patients undergoing oral and maxillofacial surgery (extraoral surgery) with general anesthesia 4, Voluntarily signed informed consent
Exclusion criteria
Exclusion criteria: 1, Recent history of drug abuse 2, Patients with preoperative cognitive dysfunction, communication disorders 3, Body mass index over 30 kg/m2 4, Preoperative sleep apnea syndrome, restless legs syndrome, etc. 5, Patients admitted to the intensive care unit after surgery 6, Liver and kidney dysfunction, the former is defined as aspartate amino transferase and (or) alanine aminotransferase levels greater than 1.5 times the upper limit of normal (ULN), the abnormal renal function is defined as serum creatinine greater than 1.5 times ULN 7, contraindicated of esketamine (be allergic to the ingredients of esketamine, at high risk of high blood pressure or high intracranial pressure, aortic dissection, poorly controlled or untreated hypertensive patients (more than 180/100 mmHg), preeclampsia and eclampsia, need to relax the uterine muscles).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sleep disorder one day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep disorder 3, 5, 30 days after surgery;anxiety scores 1, 3, 5, and 30 days after surgery;agitation score during extubation;sore throat score after extubation;pain scores at 1, 3, and 5 days after surgery;length of stay;the changes of EEG after the administration of esketamine; | — |
Countries
China
Contacts
Public ContactLiu Tiantian
The Third Affiliated Hospital of the Air Force Medical University
Outcome results
None listed