Depression
Conditions
Interventions
ECT group:Electroconvulsive therapy
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years old; 2. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), two psychiatrists independently diagnose the patients as depression; 3. a total HAMD-24 score of >20; 4. Right-handedness; 5. The patient's physical examination, medical history, vital signs, blood, urine and stool routine, liver and kidney function, electrolytes, electrocardiogram, electroencephalogram and other indicators are normal; 6. After fully understanding the safety of MST, they are willing to actively cooperate with the treatment and have their informed consent signed by themselves and their families.
Exclusion criteria
Exclusion criteria: 1. Age 60 years; 2. Those with a history of severe physical illness and depression due to other psychoactive and non-dependent substances; 3. Patients with metallic or electronic instruments placed in the body, such as intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies; 4. Patients at risk for seizures, with previous cranial disease, head trauma, alcoholism, EEG abnormalities, MRI evidence of structural abnormalities in the brain, or a family history of epilepsy; 5. Patients at risk of acute suicide; 6. Those with psychotic symptoms requiring a combination of should antipsychotic medications; 7. Receiving ECT after enrollment; 8. Those who are pregnant, breastfeeding, or planning to become pregnant during the trial; 9. Refusal to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale (HAMA) ;Self-rating Depression Scale (SDS) ;Self-rating Anxiety Scale (SAS) ;Baker Suicide Ideation Scale Chinese version (BSI-CV) ;Neuropsychological Status Rating Scale (RBANS) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electromyographic changes;Neuroelectrophysiological indicators;Brain-derived neurotrophic factor;Hamilton Depression Scale (HAMD-24) ; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed