Alzheimer's disease
Conditions
Interventions
surgery group:Cervical LVA
control group:Conventional treatment, no change in original medication habits
Sponsors
Dongguan Chashan Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Male or female outpatients aged 50-85 years old 2. Meets National Institute on Aging and Alzheimer's Association (NIA-AA) diagnostic criteria for AD 3.The estimated survival time is more than 12 months 4.ASA grading criteria for preoperative anesthesia assessment 5. Volunteer to participate in the project and sign an informed consent form with the guardian
Exclusion criteria
Exclusion criteria: 1. History of significant trauma or surgery to the neck that would affect the outcome of this procedure 2. Vascular dementia, central nervous system infections due to AIDS and syphilis, etc., Creutzfeldt-Jakob disease, Huntington's chorea and Parkinson's disease, dementia with Lewy bodies, traumatic brain injury dementia, physicochemical factors such as drug and alcohol intoxication, important somatic illnesses such as hepatic encephalopathy and pulmonary encephalopathy, endocrine system pathology such as subdural hematomas, thyroid disorders, and parathyroid disorders, as well as vitamin deficiencies or any other Dementia of any other cause 3.Presence of severe mental disorders, risk of suicide, inability to cooperate with treatment 4.literacy or insufficient education to complete the scale assessment 5.Unable to tolerate PET-CT or allergic to contrast media 6. Study sponsor or investigator decision to suspend the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PET/CT Standardized Uptake Value Ratio (SUVR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma-associated Alzheimer's marker assay;Mini-Mental State Examination;Montreal Cognitive Assessment;Activity of Daily Living; | — |
Countries
China
Contacts
Public ContactXie Qingping
Dongguan Chashan Hospital
Outcome results
None listed