Drug-refractory epilepsy
Conditions
Interventions
Group 1 (early reduction group):Antiepileptic drugs were reduced after operation (no seizures occurred at 3, 6 and 12 months after operation, and one antiepileptic drug was stopped every three months)
Group 2(late early reduction group):Antiepileptic drugs were reduced after operation (there was no seizure at 12, 18 and 24 months after operation, and one antiepileptic drug was stopped every three m
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 12 Years
Inclusion criteria
Inclusion criteria: (1) The operative age is =2 kinds of ASM; before operation; (3) There was no seizure within two weeks after epilepsy operation; (4) The lesion is located on one side, and MRI after operation shows that the lesion structure is completely removed/severed or the epileptogenic zone is completely removed/Isolation; (5) 24-hour scalp EEG after 7-14 days meets the following criteria: no persistent, disconnected from the diseased side. Except for sexual surgery) consistent and rhythmic epileptiform discharge or slow wave (local rhythmic epileptiform discharge or Slow wave, local persistent epileptiform discharge or slow wave). Note: 1) Complete resection/amputation of diseased structures: According to postoperative MRI of the head, abnormal areas of structures were completely excised or amputated; 2) Complete excision/disconnection of epileptogenic focus: The intraoperative electrocorticogram after excision did not show continuous and rhythmic epileptiform discharge consistent with the lesion.
Exclusion criteria
Exclusion criteria: (1) The patient is over 12 years old at the time of operation; (2) Oral administration of <=1 ASM; before operation; (3) Epilepsy occurred within two weeks after operation; (4) Brain MRI showed bilateral lesions; (5) The lesion is located in the functional area, and the excision/disconnection of the structural lesion or epileptogenic area is incomplete due to functional protection; (6) Postoperative MRI showed that the lesion was not completely resected/severed; (7) Intraoperative EEG monitoring showed that the epileptogenic zone was not completely excised/severed; (8) There were persistent, rhythmic epileptiform discharges or slow waves (local rhythmic epileptiform discharges or slow waves, local persistent epileptiform discharges or slow waves) in scalp EEG 24 hours after operation 7-14 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of seizure-free rate between the two groups after one-year follow-up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of developmental quotient/IQ; | — |
Countries
China
Contacts
Public ContactTaoyun Ji
Peking University First Hospital
Outcome results
None listed