Rebound Pain
Conditions
Interventions
Esmketamine:Esketamine was administered during the operation
Control:An equal volume of normal saline was administered
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: Patients scheduled for arthroscopic shoulder surgery 2: Age of 18-65 years, no gender; 3: ASA I-III 4: Patients voluntarily participated in this study and signed an informed consent form
Exclusion criteria
Exclusion criteria: 1: The patient refused; 2: Existing contraindications to ISB, such as coagulopathy, local and systemic infections. Coagulation dysfunction was defined as prothrombin time or activated partial thromboplastin time exceeding the standard value or International normalized ratio (INR) = 1.4, or platelet count 35kg/m2; 4: Allergy to test drugs or general anesthetic drugs; 5: Hepatic and renal insufficiency; 6: A history of chronic pain or opioid use; 7: A history of surgery within the last 6 months; 8: Psychiatric or neurological conditions and language problems; 9: Patients who are pregnant or lactating; 10: Sick sinus syndrome (SSS), severe bradycardia (HR < 50/min) or Atrioventricular block (AVB) grade II or higher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rebound pain after ISB; | — |
Secondary
| Measure | Time frame |
|---|---|
| difference in pain score before and after ISB resolution;time to the first analgesic request;onset time of rebound pain;Rebound pain score(NRS);duration of rebound pain;Acute pain;PCIA;Rescue analgesia;Intraoperative and Postoperative analgesic consumption (morphine equivalent);QoR-15 score; | — |
Countries
China
Contacts
Public ContactLe Zhang
The second hospital of Shandong University
Outcome results
None listed