unexplained recurrent spontaneous abortion
Conditions
Interventions
control group:None
unexplained recurrent spontaneous abortion group:drink Bushen Yangxue Prescription
Sponsors
Jiangsu Province Hospital of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? Consistent with the Western medicine diagnostic criteria referred to URSA and the TCM diagnostic criteria. ? women aged 20-40 years who get ready for pregnancy . ? All the participants provided written informed consent.
Exclusion criteria
Exclusion criteria: ? The chromosomal or genetic abnormalities ? The anatomical abnormalities of the reproductive system: abnormalities resulting from congenital dysplasia and/or posteriority uterine disease. ? The endocrine abnormalities: corpus luteum insufficiency, polycystic ovary syndrome, hyperprolactinemia, thyroid disorders, and diabetes mellitus. ? The genital tract infections: Toxoplasma, cytomegalovirus, rubella virus, herpes simplex virus, etc. ? Abnormalities of autoimmune antibodies: positive antibodies of anticardiolipin and/or antisperm, and/or antiendometrium, and/or antiovarian. ? Prethrombotic State: platelet aggregation rate and D-dimer abnormalities. ? Male Infertility: abnormal semen routine examination. ? Severe primary cardiac, hepatic, pulmonary, renal, or hematologic diseases that affect their survival, such as cancer or AIDS; clinically significant electrocardiographic abnormalities. ? Individuals who are unable to give full informed consent due to intellectual or behavioral impairments. ? Individuals who are suspected to have alcohol or drug abuse or really have. ? Other circumstances that reduce the likelihood of enrollment or complicate the enrollment, such as frequent changes in work environment, and that predispose to loss of follow-up, as judged by the investigator. ? Allergic State, such as a history of being allergic to two or more drugs or foods, or of being known to be allergic to the ingredients of the drug; ? Patients who are participating in clinical trials of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change of TCM scores;the effective pregnancy rate;Fetal status; | — |
Secondary
| Measure | Time frame |
|---|---|
| the differentiation proportion of CD4+T cell subpopulations ;the amount of NK cells;the level of Effector cytokine; | — |
Countries
China
Contacts
Public ContactCong Chen
Jiangsu Province Hospital of Chinese Medicine
Outcome results
None listed