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The Effect of transcutaneous Vagus Nerve Stimulation on Postoperative Liver Function in Patients Undergoing Liver Partial Resection with Ischemia-Reperfusion Injury: A Prospective, Double-blind, Randomized Controlled Study

The Effect of transcutaneous Vagus Nerve Stimulation on Postoperative Liver Function in Patients Undergoing Liver Partial Resection with Ischemia-Reperfusion Injury: A Prospective, Double-blind, Randomized Controlled Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400092005
Enrollment
Unknown
Registered
2024-11-07
Start date
2024-11-07
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cancer, hemangioma of the liver

Interventions

Sponsors

Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Age: 18=Y=75 years old 2. proposed to undergo elective liver resection (liver cancer, hemangioma of the liver) 3.ASA grade I to III 4. the anesthesia method is intravenous inhalation combined anesthesia 5. can understand the study process and the use of various assessment scales, can communicate effectively with researchers

Exclusion criteria

Exclusion criteria: 1. Refusal to sign the test consent; 2. Having neuropsychiatric diseases, as well as a history of neurological or psychiatric diseases, and abnormal ear anatomy affecting the instrument user; 3. Severe cardiovascular and cerebrovascular disease (myocardial infarction within the past 12 months, New York Heart Association heart rating =2, pulmonary dysfunction PaO2 442mmol/l) ; 6. Previous history of hepatectomy, 7. biliary tract disease (biliary calculus, biliary tract infection, obstruction, etc.)

Design outcomes

Primary

MeasureTime frame
alanine aminotransferase;

Secondary

MeasureTime frame
aspartate aminotransferase;Urea nitrogen;creatinine;Total bile acids;Direct bilirubin ;Total bilirubin;Tumor necrosis factor-alpha;Interleukin-6;Postoperative recovery quality score;Postoperative delirium score;Anxiety score;Fatigue grading;Gastrointestinal function recovery score;First exhaust time;Time of first defecation;First feeding time;Pain score;

Countries

China

Contacts

Public ContactJunli Cao

Affiliated Hospital of Xuzhou Medical University

caojl0310@aliyun.com+86 151 6216 0809

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026