Ovarian cancer
Conditions
Interventions
Chemotherapy group :Neoadjuvant chemotherapy was performed before surgery
Non-chemotherapy group:No neoadjuvant chemotherapy was given before surgery
Sponsors
Jiangsu Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. For patients with FIGO stage ? ~ ? ovarian cancer who were to undergo pelvic lesion resection, preoperative neoadjuvant chemotherapy was determined according to SUDAN score. Patients who received neoadjuvant chemotherapy before surgery were included in cohort 1, and those who did not received neoadjuvant chemotherapy were included in cohort 2. 2.ASA grade I ~ III 3. Age range from 18 ~ 64 4. Body mass index of 18.5 ~ 28kg/m^2 5. Patients or family members sign informed consent
Exclusion criteria
Exclusion criteria: 1. Neuromuscular disease was present before surgery 2. Diabetic patients 3. Long-term use of psychotropic drugs, chronic analgesics and drugs affecting neuromuscular conduction before surgery 4. Allergic reaction to other anesthetic drugs such as neuromuscular blocking drugs before surgery 5. Severe liver and kidney dysfunction or severe heart disease before surgery (NYHA grade ? or ?) 6. History of chemoradiotherapy for other tumors 7. Participated in other clinical studies in 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from sugammadex administration to Train of Four ratio>=0.9; | — |
Secondary
| Measure | Time frame |
|---|---|
| The onset time of muscle relaxants;Clinical duration time of muscle relaxants;Recovery index of muscle relaxants;Extubation time;Duration of postanesthesia care unit stay;Richmond Agitation-Sedation Scale score;Incidence of respiratory depression;Incidence of re-intubation;Incidence of agitation;Incidence of nausea and vomiting;Numerical rating scale scores;Time to first ambulation;Time to first flatus;Time to first meal;Length of postoperative hospital stay;Total length of hospital stay;The occurrence of postoperative complications;Systolic blood pressure;Diastolic blood pressure;Heart rate;Pulse oxygen saturation; | — |
Countries
China
Contacts
Public ContactXiaolan Gu
Jiangsu Cancer Hospital
Outcome results
None listed