The elderly patients underwent laparoscopic general anesthesia
Conditions
Interventions
Experimental group:Fospropofol disodium is used for induction and maintenance of general anesthesia
Control group:Propofol is used for induction and maintenance of general anesthesia
Sponsors
Shanxi Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Age 65-85 years old, gender unlimited (2) American Society of Anesthesiologists (ASA) : Level I-III; (3) Body mass index (BMI) : 18.5~30 kg/m^2; (4) Subjects undergoing laparoscopic colorectal cancer resection under elective general anesthesia; (5) Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Chronic users of analgesics, psychotropic drugs (including opioids, NSAIDs, sedatives, antidepressants), and alcohol abusers; (2) Patients with serious heart, brain, lung, liver, kidney and other important organ dysfunction and electrolyte abnormalities before surgery; (3) Patients with previously poorly controlled hypertension or diabetes; (4) Patients with an allergic history of intraoperative drug use, allergies to eggs, soybeans and their products, and lipid metabolism disorders; (5) Patients with prolonged QT interval indicated by preoperative electrocardiogram; (5) History of peripheral arterial and/or severe cerebrovascular diseases; (6) Patients with coagulation dysfunction; (7) Patients with expected surgical bleeding volume >1000ml; (8) Patients with preoperative cognitive dysfunction determined by MMSE scale; (9) Have participated in other drug trials within three months; (10) Patients deemed unsuitable for this study by other investigators;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation/anesthesia success rate: (percentage of successful induction and maintenance of anesthesia); | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of successful induction of anesthesia;Vital signs related indicators;Incidence and severity of cognitive dysfunction 1 and 3 days after surgery;Sleep quality scores at night 1 and 3 after surgery;Restlessness score (RS), Ramsay sedation score, VAS score;Incidence of adverse reactions;Inflammatory index: IL-6, TNF-a, IL-10, oxygen free radical index SOD, MDA content changes;Immune indicators: Changes in CD3+, CD4+, CD4+/CD8+; | — |
Countries
China
Contacts
Public ContactTing Wang
Shanxi Provincial People's Hospital
Outcome results
None listed