To explore the treatment of chronic insomnia disorder with repeative transcranial magnetic stimulation under image navigation system

To explore the treatment of chronic insomnia disorder with repeative transcranial magnetic stimulation under image navigation system - To explore the treatment of chronic insomnia disorder with rTMS under image navigation system

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400091978

Enrollment

Unknown

Registered

2024-11-06

Start date

2024-11-20

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Insomnia

Interventions

Intervention group:TMS

Pseudo stimulation group:sham stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Chronic insomnia disorder case group: diagnosed outpatient/inpatient with ICSD-3 chronic insomnia disorder, aged 14-65 years, dextromanuality; 2. The subjects meet the diagnostic criteria of ICSD-3 chronic insomnia disorder; 3. ISI>=8 points; 4. The subjects without physical therapy (such as MECT, TMS, acupuncture, etc) in the past 6 months; 5. The subjects havent use the drugs of sedative-hypnotic, antidepressants, antipsychotics, mood stabilizers, or others that effect on the central nervous system at least 4 weeks; 6. The subjects are non-shift workers; 7. The subjects with chronic insomnia = 5 years.

Exclusion criteria

Exclusion criteria: 1. The subjects were diagnosed as mental disease currently or previously according to MINI; 2. The subjects education period < 5 years or IQ < 90 points; 3. The subjects travelled across time zones within 3 months; 4. The subjects with the habit of consuming probiotics and prebiotic products; 5. The subjects suffered from nervous system disease, trauma, chronic physical diseases, brain organic diseases or tumor. 6. The patients had some sleep disorders (OSA, PLMS, RLS, etc) but except insomnia 7. The subjects who intake alcohol within 1 week before enrolling; 8. The subjects who consume coffee in the afternoon before the experiment; 9. The subjects contraindicated to MRI.

Design outcomes

Primary

Measure	Time frame
PSQI;ISI;Polysomnography (PSG);	—

Secondary

Measure	Time frame
Sleep monitoring bracelet;fMRI;PHQ-15;PHQ-9;GAD-7;MoCA;HAMA;HAMD-17;Stanford Sleepiness Scale;Beck Anxiety Inventory;Beck Depression Inventory;PANAS;Morningness-Eveningness Questionnaire;Emotion Regulation Questionnaire;Social Interaction Questionnaire;Liebowitz Social Anxiety Scale;Interpersonal Motivational System Scale;Childhood Trauma Questionnaire;Subjective Socioeconomic Status Scale;Self-Control Scale;UCLA Loneliness Scale;VFT;FFT;Treasure Hunt Maze Game Test;Electroencephalography (EEG); Near-Infrared Spectroscopy (NIRS); Magnetoencephalography (MEG);	—

Measure

Time frame

Sleep monitoring bracelet;fMRI;PHQ-15;PHQ-9;GAD-7;MoCA;HAMA;HAMD-17;Stanford Sleepiness Scale;Beck Anxiety Inventory;Beck Depression Inventory;PANAS;Morningness-Eveningness Questionnaire;Emotion Regulation Questionnaire;Social Interaction Questionnaire;Liebowitz Social Anxiety Scale;Interpersonal Motivational System Scale;Childhood Trauma Questionnaire;Subjective Socioeconomic Status Scale;Self-Control Scale;UCLA Loneliness Scale;VFT;FFT;Treasure Hunt Maze Game Test;Electroencephalography (EEG); Near-Infrared Spectroscopy (NIRS); Magnetoencephalography (MEG);

—

Countries

China

Contacts

Public ContactJun Zhang

West China Hospital of Sichuan University

1025159956@qq.com+86 189 8060 2251

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026