The Clinical Efficacy of Amantadine on Vegetative State Post-Traumatic Brain Injury

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400091956

Enrollment

Unknown

Registered

2024-11-06

Start date

2015-05-26

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury

Interventions

treatment group:the treatment group received amantadine combined with comprehensive rehabilitation treatment.

control group:the control group received comprehensive rehabilitation treatment.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Patients with vegetative state after brain injury for 4-16 weeks; (2) Age 18-65 years old, without penetrating brain injury and with stable vital signs; (3) CRS-R score = 8 points, DRS score = 20 points, Rancho Los Amigos I-III; (4) Sign an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Those whose vital signs have not stabilized or whose condition has worsened during the acute phase; (2) Individuals with poor control of seizures; (3) Complicated with severe kidney disease; (4) Individuals with severe hydrocephalus; (5) Those who take other psychotropic drugs for treatment; (6) Individuals who are allergic to amantadine.

Design outcomes

Primary

Measure	Time frame
Coma Recovery Scale-Revised score;	—

Secondary

Measure	Time frame
Disability Rating Scale score;Rancho Los Amigos Levels of Cognitive Functioning ;	—

Countries

China

Contacts

Public ContactZhenlan Li

The First Hospital of Jilin University

zhenlan@jlu.edu.cn+86 159 4305 3720

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026