laryngopharyngeal reflux
Conditions
Interventions
Case group:None
Control group:None
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 58 Years
Inclusion criteria
Inclusion criteria: Outpatient patients who do not complain of discomfort in the throat and meet the inclusion and exclusion criteria are the control group. Case group: Outpatient patients in the Department of Otolaryngology, presenting with symptoms such as foreign body sensation in the throat, persistent clearing of the throat, hoarseness, voice fatigue, sore throat, chronic cough, and difficulty breathing. The onset time is more than 3 months, RSI>13 points, and the Dx PH monitoring result is positive for LPR patients. Inclusion criteria (1) The patient is aged between 18 and 78 years old; (2) No serious systemic or mental illnesses; (3) Sign informed consent; (4) Unbeneficial habits of consuming probiotics and prebiotics.
Exclusion criteria
Exclusion criteria: (1) Patients with diabetes, hypertension, malignant tumor, respiratory system disease, endocrine disease, heart disease, arrhythmia, cardiogenic chest pain, cerebrovascular accident, upper gastrointestinal diseases, upper abdominal surgery or other serious systemic diseases; (2) Recently used drugs that have an impact on autonomic nervous system function, such as cholinergic agonists or antagonists, adrenergic agonists or antagonists, neuromuscular blockade drugs used before anesthesia, antipsychotics, immunomodulators, and prostaglandin drugs; (3) Long term smoking or excessive drinking; (4) Drinking beverages containing caffeine and alcohol within 24 hours before the experiment, resulting in significant changes in dietary structure; (5) Women during their menstrual period, pregnant or breastfeeding period; (6) Oral antibiotics and proton pump inhibitors in the past month; (7) Patients with upper respiratory tract infections and those who have been cured within 2 weeks; (8) Individuals with acute oral infections; (9) Medications that may affect the judgment of test results need to be added midway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mucin in saliva;SIgA;EGF;TGF-a;Salivary inflammatory factors;Salivary microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Salivary secretion;Non stimulating and stimulating total saliva flow rate;Salivary pH value;Salivary buffering capacity; | — |
Countries
China
Contacts
Public ContactZhang Yanping
Chinese PLA General Hospital
Outcome results
None listed