chronic pain (CPSP)
Conditions
Interventions
Dexmedetomidine:Dexmedetomidine was administered during the operation
Control:An equal volume of normal saline (NS) was administered during the operation
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1: Planned mastectomy with or without axillary or sentinel lymph node dissection or partial mastectomy (skin, areola and sparing) with axillary lymph node dissection; 2: Age>18years, female; 3: ASA I-III 4: Patients voluntarily participated in this study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1: The patient refused 2: Life expectancy is less than 2 years 3: Active malignant disease 4: Pregnant or lactating women 5: Patients who had undergone ipsilateral breast surgery within the previous 3 years 6: Preoperative chronic pain 7: Steroid or morphine allergy 8: Reported history of substance abuse 9: Cardiac insufficiency or severe hypertension 10: Hepatic/renal insufficiency 11: Psychiatric or neurological conditions and language problems 12: Allergy to dexmedetomidine or general anesthetics 13: Sick sinus syndrome (SSS), severe bradycardia (HR < 50/min) or Atrioventricular block (AVB) grade II or higher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CPSP at 3 month after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of CPSP at 6 month after surgery;The nature and characteristics of chronic postoperative pain;Rescue analgesic use and frequency;Patient satisfaction;OME;NRS; | — |
Countries
China
Contacts
Public ContactLe Zhang
The second hospital of Shandong University
Outcome results
None listed