Obesity Metabolic Disease
Conditions
Interventions
Experimental group(H1):Postoperative nasal hyperflow oxygen therapy respiratory support (40L/min,30min)
Experimental group(H2):Postoperative nasal hyperflow oxygen therapy respiratory support (40L/min,60min)
Experimental group(H3):Postoperative nasal hyperflow oxygen therapy respiratory support (60L/min,30min)
Experimental group(H4):Postoperative nasal hyperflow oxygen therapy respiratory support (60L/min,60min)
Control group:Postoperative oxygen breathing support with a common mask(50L/min,60min)
Sponsors
First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective laparoscopic gastric volume reduction surgery; 2. ASA CLASS I-III; 3.BMI>= 35 kg/m^2; 4. Surgery time>= 2 hours; 5. Age 18-65 years old; 6. Normal communication; 7. Voluntarily take the test and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Previous history of chronic obstructive pulmonary disease or asthma resulting in limited daily activities, history of neuromuscular dysfunction, heart failure (NYHA > Grade 2), restrictive pulmonary disease (TVC reduced by more than 20%), or symptoms of upper respiratory tract infection or pulmonary infection in the past 4 weeks, chest X-ray indicating pneumonia; 3.The presence of tracheotomy and any nasal or facial defects that may prevent the use of high-flow oxygen therapy or masks; 4. Allergic to the anesthetic drugs used in the study; 5. Pregnant or lactating women; 6. Inability to understand oral or written information;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index (Pao2/FiO2) after oxygen therapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and severity of postoperative pulmonary complications;Perioperative pulmonary ultrasound score;Postoperative dyspnea degree;Perioperative inflammatory indicators;Ultrasonic measurement of diaphragmatic mobility, thickness and thickening fraction after surgery;the incidence of postoperative hypoxia ;The incidences of postoperative subclinical respiratory depression;The incidences of postoperative severe hypoxia;Postoperative modified Aldrete score; | — |
Countries
China
Contacts
Public ContactKe Chen;Zihui Xu
First Affiliated Hospital of Anhui Medical University
Outcome results
None listed