mood disorder(major depressive disorder/bipolar disorder)
Conditions
Interventions
Gold Standard:ICD-10 Criteria for depressive episodes or bipolar depressive episodes
Index test:(1) Pre-processing of samples
Plasma (urine) sample 100µl or fecal sample 50mg were taken, and 300µl methanol solution (containing 4µg/ml L-2-chlorophenylalanine as the internal standard) w
2-17min, 2%-95%B
17-19min, 95%B, Posttime: 6min. HILIC: Mobile phase: 10mM ammonium formate solution of A-0.1% formic acid, B acetonitrile solution containing 0.1% formic acid, sample size: 3ul, automatic injector tem
Sponsors
Zuowei Wang
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with depressive disorder: 1. Age 18-65 years old, gender unlimited; 2. Meeting the acute phase of ICD-10 depression or bipolar depression, HAMD-17 project =14 points; 3. Junior high school education or above, having enough audio-visual level and understanding ability to complete the necessary research examination; 4. Understanding the study content and sign the informed consent. Inclusion criteria for healthy controls 1. Age 18-65 years old, gender unlimited, matching with patients with depression disorder; 2. Junior high school education or above, having enough audio-visual level and understanding ability to complete the necessary research examination; 3. Understanding the study content and sign the informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with depressive disorder 1. Currently suffering from severe and active physical disease (abnormal index > 2 times the normal value), or pharmacological conflict between current physical disease medication and antidepressant treatment; 2. Current risk of serious suicide (e.g., HAMD-17 item 3(suicide)=3 score); 3. Pregnant or lactating women, or those planning to become pregnant. Exclusion criteria for healthy controls 1. Currently suffering from mental illness; 2. Having a serious physical illness or disease that may interfere with the evaluation of the test; 3. Pregnant or lactating women, or those planning to become pregnant; 4. HAMD17 score > 7 or/and YMRS score > 10 when enrolled.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| multiple reaction monitoring-mass spectrometry;Accuracy;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactZuowei Wang
Shanghai Hongkou Mental Health Center
Outcome results
None listed