renal function
Conditions
Interventions
adult group(A Group):Intravenous anesthesia was used for induction and maintenance of anesthesia, and i.v. vecuronium 0.12mg/kg was used for induction of neuromuscular block. At the TOF ratio appeared
Elder group(E Group):Intravenous anesthesia was used for induction and maintenance of anesthesia, and i.v. vecuronium 0.12mg/kg was used for induction of neuromuscular block. At the TOF ratio appeared
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. Patients not undergoing emergency surgery scheduled for vicuronium under general anesthesia in the supine position; 2. Aged 18-74 years old, ASA classification I-II; 3.Voluntary participation in the study and signing patient informed consent
Exclusion criteria
Exclusion criteria: 1. Suffering from neuromuscular disease, liver dysfunction, heart disease and personal or family history of malignant hyperthermia, with moderate to severe renal impairment(CLCR=60ml/min); 2. Pregnant or breastfeeding women; 3. Difficult airway, sleep apnea syndrome and body mass index >= 28kg/m^2; 4. Patients who have taken the following drugs recently: aminoglycoside antibiotics, anticonvulsants, magnesium, and perioperative toremifene, fusidic acid and flucloxacillin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters ; | — |
Secondary
| Measure | Time frame |
|---|---|
| time from administration of sugammadex to recovery of tof ratio to 0.7, 0.8 and 0.9; | — |
Countries
China
Contacts
Public ContactTang Yiyang
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed